Effects of official information and rumor on resource-epidemic coevolution dynamics

Epidemic-related information and resources have proven to have a significant impact on the spread of the epidemic during the Corona Virus Disease 2019 (COVID-19) pandemic. The various orientation role of information has different effects on the epidemic spreading process, which will affect the individual’ awareness of resources allocation and epidemic spreading scale. Based on this, a three-layer network is established to describe the dynamic coevolution process among information dissemination, resource allocation, and epidemic spreading. In order to analyze dynamic coevolution process, the microscopic Markov chain (MMC) theory is used. Then, the threshold of epidemic spreading is deduced. Our results indicated that the official information orientation intensity inhibits the epidemics spreading, while rumor orientation intensity promotes epidemic spreading. At the same time, the efficiency of resource utilization restrains the expansion of the infection scale. The two kinds of information are combined with resources respectively. Official information will enhance the inhibitory effect of resources epidemics spreading, while rumor will do the opposite.

ModViz: A Modular and Extensible Architecture for Drill-Down and Visualization of Complex Data

Analysis of data sets that may be changing often or in real-time, consists of at least three important synchronized components: i) figuring out what to infer (objectives), ii) analysis or computation of those objectives, and iii) understanding of the results which may require drill-down and/or visualization. There is considerable research on the first two of the above components whereas understanding actionable inferences through visualization has not been addressed properly. Visualization is an important step towards both understanding (especially by non-experts) and inferring the actions that need to be taken. As an example, for Covid-19, knowing regions (say, at the county or state level) that have seen a spike or are prone to a spike in the near future may warrant additional actions with respect to gatherings, business opening hours, etc. This paper focuses on a modular and extensible architecture for visualization of base as well as analyzed data. This paper proposes a modular architecture of a dashboard for user interaction, visualization management, and support for complex analysis of base data. The contributions of this paper are: i) extensibility of the architecture providing flexibility to add additional analysis, visualizations, and user interactions without changing the workflow, ii) decoupling of the functional modules to ease and speed up development by different groups, and iii) supporting concurrent users and addressing efficiency issues for display response time. This paper uses Multilayer Networks (or MLNs) for analysis. To showcase the above, we present the architecture of a visualization dashboard, termed CoWiz++ (for Covid Wizard), and elaborate on how web-based user interaction and display components are interfaced seamlessly with the back-end modules. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Drug Repositioning Using Multiplex-Heterogeneous Network Embedding: A Case Study on SARS-CoV2

Drug repositioning (also called drug repurposing) is a strategy for identifying new therapeutic targets for existing drugs. This approach is of great importance in pharmacology as it is a faster and cheaper way to develop new medical treatments. In this paper, we present, to our knowledge, the first application of multiplex-heterogeneous network embedding to drug repositioning. Network embedding learns the vector representations of nodes, opening the whole machine learning toolbox for a wide variety of applications including link prediction, node labelling or clustering. So far, the application of network embedding for drug repositioning focused on heterogeneous networks. Our approach for drug repositioning is based on multiplex-heterogeneous network embedding. Such method allows the richness and complexity of multiplex and heterogeneous networks to be projected in the same vector space. In other words, multiplex-heterogeneous networks aggregate different multi-omics data in the same network representation. We validate the approach on a task of link prediction and on a case study for SARS-CoV2 drug repositioning. Experimental results show that our approach is highly robust and effective for finding new drug-target associations. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Integrated network analysis reveals new genes suggesting COVID-19 chronic effects and treatment.

The COVID-19 disease led to an unprecedented health emergency, still ongoing worldwide. Given the lack of a vaccine or a clear therapeutic strategy to counteract the infection as well as its secondary effects, there is currently a pressing need to generate new insights into the SARS-CoV-2 induced host response. Biomedical data can help to investigate new aspects of the COVID-19 pathogenesis, but source heterogeneity represents a major drawback and limitation. In this work, we applied data integration methods to develop a Unified Knowledge Space (UKS) and used it to identify a new set of genes associated with SARS-CoV-2 host response, both in vitro and in vivo. Functional analysis of these genes reveals possible long-term systemic effects of the infection, such as vascular remodelling and fibrosis. Finally, we identified a set of potentially relevant drugs targeting proteins involved in multiple steps of the host response to the virus.

Modeling the competitive diffusions of rumor and knowledge and the impacts on epidemic spreading.

The interaction between epidemic spreading and information diffusion is an interdisciplinary research problem. During an epidemic, people tend to take self-protective measures to reduce the infection risk. However, with the diffusion of rumor, people may be difficult to make an appropriate choice. How to reduce the negative impact of rumor and to control epidemic has become a critical issue in the social network. Elaborate mathematical model is instructive to understand such complex dynamics. In this paper, we develop a two-layer network to model the interaction between the spread of epidemic and the competitive diffusions of information. The results show that knowledge diffusion can eradicate both rumor and epidemic, where the penetration intensity of knowledge into rumor plays a vital role. Specifically, the penetration intensity of knowledge significantly increases the thresholds for rumor and epidemic to break out, even when the self-protective measure is not perfectly effective. But eradicating rumor shouldn't be equated with eradicating epidemic. The epidemic can be eradicated with rumor still diffusing, and the epidemic may keep spreading with rumor being eradicated. Moreover, the communication-layer network structure greatly affects the spread of epidemic in the contact-layer network. When people have more connections in the communication-layer network, the knowledge is more likely to diffuse widely, and the rumor and epidemic can be eradicated more efficiently. When the communication-layer network is sparse, a larger penetration intensity of knowledge into rumor is required to promote the diffusion of knowledge.